6A · Sensing, perceiving, and responding

Sensing the environment

PsychBio

How raw physical energy becomes neural signals (sensation), how the brain organizes those signals into a usable world (perception), the limits of what we can detect (thresholds), and the machinery of each sense.

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Sensory processing & psychophysics

Psych high-yield

The study of how physical stimuli relate to the sensations we experience — thresholds, the just-noticeable difference, and signal detection.

Transduction is the conversion of physical/chemical stimulus energy into an electrochemical (neural) signal by a sensory receptor. Bottom-up processing builds perception from the raw sensory data up; top-down processing uses prior knowledge and expectations to interpret. Key receptor types recur across senses: photoreceptors (light), hair cells (sound, balance), chemoreceptors (taste, smell), mechanoreceptors (touch, pressure), thermoreceptors, and nociceptors (pain).

Thresholds & Weber's law

term Psych high-yield

The absolute threshold is the minimum stimulus detectable 50% of the time; the difference threshold (JND) is the smallest detectable change, and by Weber's law it's a constant percentage of the original stimulus, not a fixed amount.

Subliminal stimuli fall below the absolute threshold (below conscious detection). The threshold of conscious perception is distinct from the absolute threshold. Sensory adaptation is the decline in receptor sensitivity to a constant stimulus (you stop feeling your clothes). Weber's law explains why adding one candle to a dark room is obvious but adding one to a bright room isn't — the JND scales with intensity.

Don't confuse

Sensory adaptation (receptor-level, a constant stimulus) vs. habituation (a behavioral/cognitive decrease, from 7C). AAMC offers them as a pair.

Signal detection theory

theory Psych high-yield

Detection depends not just on the stimulus but on the observer's decision process. Outcomes are hits, misses, false alarms, and correct rejections, split into sensitivity (d′) and response bias.

Signal detection theory says there's no fixed threshold; whether you report a stimulus depends on sensitivity (how well you actually discriminate signal from noise) and response bias/criterion (your willingness to say "yes," shaped by expectations, motivation, and the costs/rewards of each outcome). A radiologist primed to find tumors raises hits and false alarms.

How AAMC tests it

A passage manipulates payoffs or expectations and asks how hits/false alarms shift — that's response bias, not a change in true sensitivity.

Vision

PsychBio high-yield

Light is focused onto the retina, transduced by rods and cones, and routed to the visual cortex; color is explained by two complementary theories.

Light passes the corneapupil (sized by the iris) → lens (which changes shape, accommodation, to focus) → onto the retina. Photoreceptors transduce light: rods (very light-sensitive, peripheral, night/dim vision, no color) and cones (color and fine acuity, concentrated in the fovea). Signals pass through bipolar and ganglion cells, whose axons form the optic nerve (the exit point is the optic disc / blind spot). The pathway runs via the optic chiasm and LGN of the thalamus to the visual cortex; feature detectors (Hubel & Wiesel) respond to specific features, and parallel processing handles color, motion, form, and depth simultaneously.

Light is focused through the cornea and lens onto the fovea; rods and cones transduce it and relay the signal through bipolar and ganglion cells to the optic nerve. The optic disc — where the nerve exits — has no photoreceptors, creating the blind spot.
Cross-section of the human eye labeling the cornea, pupil, iris, lens, ciliary body, sclera, retina, fovea, optic disc (blind spot), and optic nerve, with an inset of the retinal cell layers showing rods and cones, bipolar cells, and ganglion cells.

Light is focused through the cornea and lens onto the fovea; rods and cones transduce it and relay the signal through bipolar and ganglion cells to the optic nerve. The optic disc — where the nerve exits — has no photoreceptors, creating the blind spot.

Trichromatic vs. opponent-process theory

distinction Psych high-yield trap

Trichromatic (Young-Helmholtz) theory: three cone types (red/green/blue) combine to make all colors. Opponent-process theory: color is coded in opposing pairs (red–green, blue–yellow, black–white), explaining afterimages.

Both are correct at different stages: trichromatic at the cone (receptor) level, opponent-process at the ganglion/LGN (neural processing) level. Negative afterimages (stare at green, see red) are the classic opponent-process evidence; color blindness (missing/defective cones) is trichromatic evidence.

Don't confuse

Which theory explains afterimages? → opponent-process. Which explains color blindness from missing cones? → trichromatic.

Hearing (audition)

PsychBio med-yield

Sound waves are funneled through the ear, vibrate the ossicles and cochlear fluid, and bend hair cells; pitch is encoded by two theories.

Path: pinnaauditory canaltympanic membrane (eardrum) → the ossicles (malleus, incus, stapes) → oval windowcochlea, where fluid waves move the basilar membrane and bend hair cells (the organ of Corti) to transduce sound. Loudness is coded by amplitude; pitch by the two theories below. Conductive hearing loss (a mechanical problem in the outer/middle ear) vs. sensorineural loss (damage to the cochlea/hair cells or auditory nerve) is worth knowing.

Sound funnels through the pinna and auditory canal to vibrate the tympanic membrane; the malleus, incus, and stapes amplify the vibration to the oval window, creating fluid waves in the cochlea that bend hair cells in the organ of Corti to transduce sound.
Cross-section of the human ear showing the outer ear (pinna, auditory canal), middle ear (tympanic membrane, malleus, incus, stapes, oval window), and inner ear (cochlea, semicircular canals, vestibulocochlear nerve), with an inset of the organ of Corti showing hair cells on the basilar membrane.

Sound funnels through the pinna and auditory canal to vibrate the tympanic membrane; the malleus, incus, and stapes amplify the vibration to the oval window, creating fluid waves in the cochlea that bend hair cells in the organ of Corti to transduce sound.

Place vs. frequency theory

distinction Psych med-yield

Place theory — pitch is coded by which spot on the basilar membrane vibrates most (explains high frequencies). Frequency (temporal) theory — pitch is coded by the rate of neural firing matching the sound's frequency (explains low frequencies); the volley principle extends it.

The other senses

PsychBio med-yield

Touch/pain (somatosensation), taste, smell, body position (kinesthetic), and balance (vestibular).

  • Somatosensation — touch, pressure, temperature, and pain. The gate control theory of pain: a neural "gate" in the spinal cord can block or allow pain signals, explaining why rubbing an injury or distraction reduces pain.
  • Taste (gustation)chemoreceptors in taste buds on papillae; five basic tastes (sweet, sour, salty, bitter, umami).
  • Smell (olfaction)olfactory chemoreceptors; the only sense not routed through the thalamus (it projects directly to the cortex and limbic system, tying smell tightly to memory and emotion). Pheromones signal between members of a species.
  • Kinesthetic sense (proprioception) — position and movement of body parts.
  • Vestibular sense — balance and spatial orientation, via the semicircular canals and otolith organs of the inner ear.
Four papilla types cover the tongue. Fungiform, circumvallate, and foliate papillae carry taste buds; filiform papillae are keratinized and mechanical only — they have no taste buds.
Top-down view of the tongue showing the four types of lingual papillae at their locations — filiform across the surface, fungiform scattered on the tip and sides, circumvallate in a V-shaped row at the back, and foliate on the posterior lateral edges — each with a cross-section inset. Taste buds are shown in the fungiform, circumvallate, and foliate papillae; filiform papillae have none.

Four papilla types cover the tongue. Fungiform, circumvallate, and foliate papillae carry taste buds; filiform papillae are keratinized and mechanical only — they have no taste buds.

Mechanoreceptors sit at different depths and encode different stimuli — free nerve endings (pain/temperature), Meissner's corpuscles (light touch), Merkel cells (pressure/texture), Ruffini endings (stretch), and the deep Pacinian corpuscle (deep pressure and vibration).
Cross-section of human skin (epidermis, dermis, hypodermis) showing somatosensory receptors at their characteristic depths: free nerve endings reaching into the epidermis (pain and temperature), Merkel cells at the epidermal base (pressure and texture), Meissner's corpuscle in the upper dermis (light touch), Ruffini endings in the dermis (skin stretch), and the deep, onion-layered Pacinian corpuscle (deep pressure and vibration).

Mechanoreceptors sit at different depths and encode different stimuli — free nerve endings (pain/temperature), Meissner's corpuscles (light touch), Merkel cells (pressure/texture), Ruffini endings (stretch), and the deep Pacinian corpuscle (deep pressure and vibration).

Smell is the only sense that reaches the cortex without relaying through the thalamus: olfactory receptor neurons → olfactory bulb → olfactory tract → cortex and limbic system, directly.
Sagittal section of the head showing the olfactory pathway: odorants in the nasal cavity stimulate olfactory receptor neurons in the olfactory epithelium, whose axons pass through the cribriform plate to the olfactory bulb, then travel via the olfactory tract directly to the cerebral cortex and limbic system — bypassing the thalamus.

Smell is the only sense that reaches the cortex without relaying through the thalamus: olfactory receptor neurons → olfactory bulb → olfactory tract → cortex and limbic system, directly.

Perception & perceptual organization

Psych high-yield

How the brain organizes sensations into coherent objects and scenes — Gestalt grouping, depth, and constancy.

Gestalt principles describe how we group elements into wholes: proximity (near things group), similarity, good continuation, closure (we fill gaps), and figure-ground (we separate an object from its background). Depth perception uses binocular cuesretinal (binocular) disparity and convergence — and monocular cues — relative size, interposition (overlap), linear perspective, texture gradient, and motion parallax. Perceptual constancy keeps size, shape, and color stable despite changing retinal images.

How AAMC tests it

Name the Gestalt principle or depth cue at work in a described image, or identify constancy when an object is perceived as stable despite a changed sensory input.

Worked question

A radiologist is told the next set of mammograms comes from a high-risk clinic. She then reports more suspected tumors than usual, including several findings later confirmed to be healthy tissue. This shift is best explained by a change in her:

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